Kominami Shizuka is a mild-mannered college student who is having trouble adjusting to city life. One day, she meets Kirishima Ryou, another student who projects the image of a cool older sister. The two hit it off, but Shizuka is shocked when Ryou attempts to seduce her. Shizuka initially assumes that Ryou is a lesbian, but Ryou is in fact a man who dresses like a lady.

In the near future, Earth is at war with aliens called Worms. The war leaves the population of Earth decimated, with young men the main casualties. The Worms were beaten back but their re-emergence heralds the creation of a mecha unit called the Sonic Divers, piloted by 3 young girls to counter this threat.

In the year 2079 AD, the mysterious mechanical cell clusters, know as Worms, begin the Human Being Sweep Operation. After a two-year war, one-third of the human race was wiped out. Finally setting national differences aside, in desperation, mankind reluctantly decides to use weapons of mass destruction. However, the victory against the Worms came at an enormous price: All the major continents were broken apart, Antarctica disappears, and half of the remaining land masses were submerged. Additionally 90% of the military personnel died, namely men in their twenties and thirties.Three years later, the supposedly destroyed enemy shows signs of activity again, near Midway. Special Vessel Koryu is sent in to reconnoitre, carrying three Sonic Diver unit fighters — the Aviation Exoskeleton Sky Divers:Reijin, Fujin, and Raijin, piloted by the Sky Girls, Sakurano Otoha, Sonomiya Karen, and Ichijou Eika respectively.The battles with an unfathomable enemy will challenge the three young, courageous test pilots to their utmost...

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Sakuragi Hanamichi is a junior high punk used to getting into fights and being rejected by girls but upon entering high school he meets the girl of his dreams, Haruko Akagi. He will do anything in order to win her heart including joining the school basketball team that is aiming to conquer the nation lead by Haruko’s brother. The problem is that Sakuragi has never played basketball before and a freshman sensation is stealing the spotlight and Haruko’s affection from him.

Hanamichi Sakuragi, infamous for this temper, massive height, and fire-red hair, enrolls in Shohoku High, hoping to finally get a girlfriend and break his record of being rejected 50 consecutive times in middle school. His notoriety precedes him, however, leading to him being avoided by most students. Soon, after certain events, Hanamichi is left with two unwavering thoughts: "I hate basketball," and "I desperately need a girlfriend." One day, a girl named Haruko Akagi approaches him without any knowledge of his troublemaking and asks him if he likes basketball. Hanamichi immediately falls head over heels in love with her, blurting out a fervent affirmative. She then leads him to the gymnasium, where she asks him if he can do a slam dunk. In an attempt to impress Haruko, he makes the leap, but overshoots, instead slamming his head straight into the blackboard. When Haruko informs the basketball team's captain of Hanamichi's near-inhuman physical capabilities, he slowly finds himself drawn into the camaraderie and competition of the sport he had previously held resentment for.

Sakuragi and the Shohoku team takes on Oda and Takezono High School. This is Sakuragi's second match as he faces Oda, a basketball player who went to the same junior high.

Ichiro Mizusawa, a player from Rukawa's old junior high school, Tomigoaka, is diagnosed with a crippling leg condition and wants to play one last game with Rukawa. Hanamichi sets out to help the boy and fulfill his wish.

After losing the titanic match against Kainan High, Team Shohoku and a newly shaven Hanamichi Sakuragi are challenged to an exhibition match by virtual basketball unknowns Ryoukufu High. Coach Anzai sees this as an opportunity for Shohoku to regain their confidence, but Ryoukufu are revealed to have a newly assembled championship calibre lineup and may give Sakuragi & Co their toughest test yet.

Set during the Inter High Championships, Shohoku take on Tsukubu, one of this year's dark horses. It's a clash of acquaintances as Anzai will face his former student which is now the coach of Tsukubu, while Akagi & Kogure meet Godai their former classmate and Tsukubu's captain. Finally Sakuragi is irked by the presence of Nango, Tsukubu's center, who vies for Haruko's attention.

Swordsman Baron travels the world of Arad to find a way to heal his demonic left arm. Accompanying him is Roxy, the ghost of a woman who unwillingly unleashed the evil that also caused Barons transformation. On their travel they get to know other fighters who accompany them and soon they call their group the “Party”.

Lina Inverse, a wandering sorceress and bandit-killer, joins forces with roving swordsman Gourry Gabriev in what’s supposed to be a quick union of convenience. Instead, an artifact Lina “liberated” from a gang of thieves turns out to be the key to the resurrection of the demon lord Shabranigdo. Urged on by the mysterious Red Priest Rezo, the pair has no choice but to fight the dark lord and his servants, accumulating new allies and enemies along the way.